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Città di Castello is a town in the province of Perugia, in the northern part of the Umbria region of Italy. It is situated on a slope of the Apennines, on the upper part of the flood plain of the nearby river Tiber. The city lies north from Perugia (46 km) and south from Cesena (104 km) on the S3bis. It is connected to the A1 Rome-Florence highway by the SS 73 from Arezzo.

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